I've killed a dozen or so whitetails since 2011 with a .41mag revolver, and every one of them had two holes in it, none went over 100 yards, some didn't make it 40 or 50. my hand loads are 210 grain Hornady XTP's going roughly 1200fps. this is an extremely accurate and fairly hot load (13.5 grains of Blue Dot, which exceeds my reloading manuals maximum charge by .5 grains) but I'm taking bow shots with this gun. longest shot has been about 40 yards, most 25 or less. I've had good results with this relatively heavy/slow load, and I'd be leaning that direction with any handgun for hunting. you can kill a deer with a 10mm, no doubt about it.