Jesse,
I would suggest leaning toward the .270 or simular caliber, for the knock down power. Shot placement is everything, but having a little more power is always a good thing.
I know when pros are hired to eliminate coyotes, they use larger calibers, so as to anchor the coyote if a follow-up shot is needed. Pryor to purchasing my .25-06 I had considered .308, .30-06 and 300 Weatherby. However, it's flatter than a road killed squirrel around here, so background is a concern. :smiley_arrogant:
Bowhunter57