I don't see how it won't interfere in some way if the seat/safety rail is at the proper sitting height when you are set up. it's possible that you could lean out enough so that the bowstring won't hit it when you are at full draw, but that might fuck up your shooting form enough to cause worse problem. every stand that I've hunted out of that had any sort of safety rail, be that a permanent wooden stand or a climber, the rail is in the way to some extent. I hate the damn things and don't own a tree stand that has one. and this is why I have a Lone Wolf with hand climber and will avoid "sit and climb" types of stands as long as I'm physically able. I've even had the seat/hand climber get in the way when I forgot to fold it down and tried to shoot while facing the tree. best thing to do is put stand on a utility pole or tree in your yard and try it out at ground level before you try to hunt out of it.