First off mink are critters of habit who are very repetitious when it comes to travel routes and hunting grounds. I use this to my advantage when ever possible. They also have a very high metabolism and need to eat often which forces them to hunt accordingly. They do have a fairly large home range, but will be back in an area they have visited before. It may take awhile, but they will be back. They tend to hole up in spots along the way. Watch for tracks going into abandon holes and old beaver huts. They have to come back out, so you need to survey the area and look for spots to nab them.
I'm a die hard blind set guy when it comes to mink. Not that I don't catch my share in baited sets as well, but the majority of my catches are in blind sets. Primarily, I target pinch points for my blind sets. This can be where a mink is running a creek bank and is forced in the water, or vice versa. These spots are perfect for a foothold under about an inch of water. Keep in mind they have very short legs and need to swim soon after the water deepens, so pan depth needs to be shallow. Also, a mink doesn't weigh much, so it doesn't take a big trap to hold them down. I do occasionally set up a drowning set but not often. Most times just staking in a foot or two of water with a longer chain is sufficient.
Like I said, look for pinch points or something that will funnel the mink to your set. You can also place a rock/log, or whatever you have at hand to create a pinch point. It isn't rocket science, just use your imagination and keep it simple. Overhanging root tangles are favorites for mink and they love to check them for prey. Mink are well known for hunting water, but they spend a ton of time on dry land as well. Tall grass/ weeds up on the creek banks are loaded with mice and other food, and provide great spots for trail sets. These can be set up with 110's and snares. After a heavy rain, there's lots of small minnows, frogs, etc that get washed up in these weeds and mink take advantage of the free meals.
There's a lot more I can go on about, but this should get you started. I'll be back on the boards more often now and will keep an eye on this thread, so feel free to ask questions.
Dale